Human Sera
Cayman Chemical RnolazInhydrochlorIde 50mg
A piperazine derivative with cardioprotective activity; reduces INa in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM); reduces IKr in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively); reduces clofilium-induced prolongation of the QTc interval and TdP in rabbits at 480 μg/kg per min; reduces interstitial collagen deposition as well as ANP, CTGF, BNP, and MMP-2 mRNA levels, and prevents left ventricular dilation in a mouse model of doxorubicin-induced cardiotoxicity
Cayman Chemical TolterodIntartrate 50mg
A muscarinic acetylcholine receptor antagonist (Kis = 1.4, 2.7, 3.6, 3.1, and 2.2 nM for M1-5 receptors, respectively); reduces carbachol-induced intracellular calcium mobilization in bladder smooth muscle cells and submandibular gland cells isolated from cynomolgus monkeys (Kis = 3.16 and 2 nM, respectively); inhibits volume-induced bladder contractions and oxotremorine-induced salivation in rats (ID50s = 0.025 and 0.12 mg/kg, respectively)
Cayman Chemical DoxorubIcInhydrochlorIde 50mg
An anthracycline antitumor antibiotic agent that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks; inhibits nucleic acid synthesis and induces apoptosis by intercalating within DNA
Cayman Chemical 5Cyno2 3dI ptolyltetra 50mg
A redox-sensitive tetrazolium salt used primarily to detect metabolic activity in microorganisms; readily taken up by living cells and reduced by respiratory activity to produce a red fluorescent, water-insoluble formazan crystal (absorption maximum at 450 nm)
Cayman Chemical Esomeprazole 50mg
An H+/K+-ATPase inhibitor; reversibly inhibits the activity of the H+/K+-ATPase in an enzyme assay; inhibits histamine-induced gastric acid secretion in rats at 30 mg/kg, s.c.
Cayman Chemical MT-1207hydrochlorIde 50mg
An α1-adrenergic and 5-HT2A receptor antagonist (IC50s = 2A- and α2B-adrenergic and 5-HT1A, 5-HT1B, 5-HT2B, and 5-HT2C receptors (IC50s = 18.1, 4.89, 4.68, 41, 11.5, and 26 nM, respectively), among others; decreases systolic and diastolic blood pressure and heart rate in spontaneously hypertensive rats and 2K-1C renal hypertensive dogs at 10 and 4 mg/kg, respectively
Cayman Chemical PnaxatrIol 100mg
A sapogenin with diverse biological activities; inhibits the proliferation of human DU15 prostate cancer cells (IC50 = 30 μM) and induces apoptosis by increasing production of ROS and decreasing mitochondrial membrane potential; reduces ischemia and reperfusion-induced myocardial dysfunction, increases LVDevP and GSH levels, and decreases cardiac LDH, CK, and MDA levels in isolated rats at 5 mg/kg for seven consecutive days prior to injury; decreases fasting blood glucose levels in KKAy insulin-resistant mice at 0.2% in chow for 6 weeks
Cayman Chemical Chrysnthemum LInarIn 50mg
A flavonoid glycoside with diverse biological activities; potentiates TRAIL-induced cytotoxicity and apoptosis in U87MG human glioma cells; potentiates TRAIL-induced tumor cell apoptosis and reduction of tumor growth in a U87MG mouse xenograft model; reduces pulmonary platelet count, edema, and macrophage, polymorphonuclear leukocyte, and lymphocyte infiltration, as well as inhibits TXNIP/NLRP3, MAPK, and NF-κB signaling in a mouse model of LPS-induced acute lung injury from 12.5-50 mg/kg; inhibits AChE and induces dyskinesia recovery in a zebrafish model of Alzheimer's disease in tank water at 50 μg/ml
Cayman Chemical AmInoacetonhydrochlorIde 50mg
A threonine and glycine catabolite that can be converted to methylglyoxal by amine oxidases; at 0.10-5 mM acts as a pro-oxidant inducing cell death in RINm5f pancreatic β-cells; used as a growth substrate for Pseudomonas
Cayman Chemical 2AmInopurInhydrochLRIde 100mg
A fluorescent analog of guanosine and adenosine that is used as a site-specific probe of nucleic acid structure and dynamics, such as studies of base stacking interactions and DNA base flipping; ex/em = 320/381 nm, respectively, when adjusted to reduce interference with DNA base absorption as well as tryptophan fluorescence; inhibits PKR
Cayman Chemical PhentolamInmesylate 50mg
A reversible antagonist of α-adrenergic receptors, non-specifically binding all α1- and α2-adrenoceptors with nanomolar affinities; rapidly and transiently increases local blood flow
Cayman Chemical SotalolhydrochlorIde 50mg
A β-AR antagonist (IC50s = 8.9 and 5.2 μM for β1- and β2-ARs, respectively) and a class III antiarrhythmic agent; decreases IK in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles at 100 μM; decreases heart rate and increases blood pressure and the cardiac FRP in a canine model of PES-induced ventricular tachycardia
Cayman Chemical MeclIzInhydrochlorIde 50mg
A histamine H1 receptor antagonist (Ki = 250 nM); reduces ovalbumin-induced mast cell degranulation, edema and leukocyte influx in rat lung from 2.5-30 mg/kg
Cayman Chemical PalIperIdon 50mg
An atypical antipsychotic; an inverse agonist of dopamine D2 and D3 receptors (IC50s = 1 and 0.9 nM, respectively) as well as an antagonist at these receptors (Kis = 0.4 and 0.1 nM, respectively); binds to α1- and α2-adrenergic receptors, histamine H1 receptors, and the 5-HT receptor subtypes 5-HT1A , 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 10.1, 80, 3.4, 480, 19, 1.21, and 48 nM, respectively); improves spatial working memory in a T-maze alternation task in a maternal immune activation mouse model of schizophrenia at 0.05 mg/kg per day; an active metabolite of risperidone
Cayman Chemical OseltamIvIrphosphate 100mg
An antiviral prodrug targeted against the influenza viruses; once hydrolyzed to its active metabolite, it can competitively inhibit viral neuraminidase (IC50s = 0.1-4.9 nM for influenza neuraminidases A and B)