Human Sera
Cayman Chemical DeltamethrIn 100mg
A macrolide antibiotic active against Gram-positive and Gram-negative bacteria including C. trachomatis and C. pneumoniae (MICs 0.125-0.5 and 0.25-1 g/ml respectively) inhibits growth of multidrug resistant P. falciparum in vitro (IC50s 0.5 nM for both Dd2 and 7G8 strains) eradicates P. berghei infection in mice when administered in a four-dose series at 100 mg/kg
Cayman Chemical AlmotrIptnmalate 50mg
A dual inhibitor of c-Met and VEGFR2 inhibits autophosphorylation of c-Met and phosphorylation of VEGFR2 (IC50s 14 and 16 nM respectively) inhibits proliferation in a variety of cancer cell lines inhibits proliferation of HUVECs stimulated with HGF and VEGF but not bFGF (IC50s 17 84 and 1000 nM) reduces tumor volume dose-dependently in nude mouse xenograft models using MKN45 Hs746T SNU-5 or EBC-1 cells increases survival of nude mice implanted with MKN45 cancer cells
Cayman Chemical PhosphatIdylserInbovIn 50mg
An oxazolidinone-type antibiotic has activity against a panel of C. difficile strains (MICs 0.125-0.5 g/ml) inhibits toxin A and B formation in stationary-phase cultures and spore formation in late exponential cultures of the toxigenic C. difficile strain ATCC 9689 inhibits C. difficile protein synthesis (IC50s 0.08-0.31 g/ml) increases survival in a mouse model of CDAD at 1 and 10 mg/kg increases survival in a hamster model of CDAD at 3 mg/kg
Cayman Chemical 5 6-epoxy Cholestnol 100mg
A metabolite of xylazine has been used as a marker for xylazine doping in MS analysis of equine urine
Cayman Chemical TrIadImenol 100mg
A non-nucleoside reverse transcriptase inhibitor inhibits growth of wild-type (EC50 0.51 nM) and NNRTI-resistant HIV strains (EC50s 1 nM for L100I K103N V106A G190A and G190S mutants) reduces the plasma viral titer in HIV-1 infected humanized mice when used in combination with cabotegravir lamivudine and abcavir
Cayman Chemical RaltItrexed 100mg
An inactive analog of the PKD inhibitor CID755673 does not bind PKD1 in a fluorescence polarization assay and has no effect on PKD1 phosphorylation in LNCaP cancer cells
Cayman Chemical DIphenylamIn 100mg
A metabolite of doxorubicin inhibits mitochondrial succinoxidase from bovine heart reduces the mitochondrial inner membrane potential in rat heart and liver mitochondria increases pentose phosphate pathway flux by 45 and reduces activity of GPx and SOD by 17 and 60 respectively in human erythrocytes at 40 M induces cytotoxicity in patient-derived ovarian cancer colonies
Cayman Chemical DodecylphosphocholIn-d38 100mg
A sulfonylurea inhibitor of SUR1/KIR6.2 (IC50 4.2 UM) enhances glucose uptake when used in combination with insulin reduces glomerulosclerosis and albumin excretion in a rat model of insulin-dependent diabetes (128 mg/kg)
Cayman Chemical DapnsutrIle 50mg
An NPSR antagonist (IC50s 22 and 23.8 nM for the NPSR Asn107 and NPSR Ile107 isoforms respectively) selective for NPSR over a panel of 14 G protein-coupled receptors exhibiting no activity at a concentration of 10 M reduces NPS-induced horizontal activity and vertical rearing and climbing in mice when administered at a dose of 50 mg/kg reduces conditioned reinstatement of cocaine seeking in rats
Cayman Chemical ThIamethoxam 100mg
A metabolite of doxorubicin inhibits mitochondrial succinoxidase from bovine heart reduces the mitochondrial inner membrane potential in rat heart and liver mitochondria increases pentose phosphate pathway flux by 45 and reduces activity of GPx and SOD by 17 and 60 respectively in human erythrocytes at 40 M induces cytotoxicity in patient-derived ovarian cancer colonies
Cayman Chemical 3MethylquInoxalIn2carboxy 50mg
An antagonist of muscarinic acetylcholine receptors (Kis 5 14.5 3.7 5.3 and 40 nM for human recombinant M1-5 respectively) inhibits carbachol- induced intracellular calcium mobilization in bladder smooth muscle and submandibular gland cells isolated from cynomolgus monkeys (Kis 2 and 1 nM respectively) inhibits VIBC and OIS in rats (ID50s 0.062 and 0.089 mg/kg respectively) increases PD and LMA (ED50s 0.29 and 0.52 mg/kg respectively) and decreases SIT (ID50 0.22 mg/kg) in rats
Cayman Chemical 4MethyLMbelIferylaDGluc 50mg
A potent and selective SPHK1 inhibitor (Kis 0.048 and 10 M for SPHK1 and 2 respectively) induces a concentration-dependent decrease in U937 cells decreases blood levels of S1P in a dose-dependent manner in rats
Cayman Chemical Caproyl TetrapeptIde3acet 50mg
An internal standard for the quantification of axitinib by GC- or LC-MS
Cayman Chemical OxysophocarpIn 50mg
A group I PAK inhibitor (IC50s 8 25 39 5 and 55 3 nM for PAK1 PAK2 and PAK3 respectively) selective for group I PAKs over PAK4 (IC50 779 nM) reverses decreases in the mean density of apical dendritic spines in the temporal cortex in the Fmr1-/- mouse model of fragile X syndrome at 20 mg/kg completely abolishes audiogenic seizures hyperactivity and stereotypical movements in Fmr1-/- mice at 30 mg/kg events adolescent cortical dendritic spine loss and rescues prepulse inhibition deficits in a Disc1 knockdown mouse model of schizophrenia
Cayman Chemical DapIprazolehydrochlorIde 100mg
A medium-chain acylcarnitine has been used in the synthesis of acylcarnitine benzyl esters